In the European region, there are multiple stock exchanges among which five are considered major (as having a market cap of over US$1 trillion):

Euronext, which is a Pan-European Dutch-domiciled France-headquartered stock exchange composed of seven market places in Belgium, France, Ireland, the Netherlands, Italy, Norway, and Portugal.

London Stock Exchange Group, which is a global stock exchange composed of the London Stock Exchange.

Deutsche Börse, which operates Europe's third largest stock exchange, the Frankfurt Stock Exchange/Xetra.

SIX Swiss Exchange, which operates Switzerland's major stock exchange.

Nasdaq Nordic, which is composed of Scandinavian and Baltic stock exchanges; including Sweden, Denmark, Finland, Iceland, Estonia, Latvia, and Lithuania, with activity in Norway and the Faroe Islands.

The main indices are:

EURO STOXX 50: - The EURO STOXX 50 is a stock index of Eurozone stocks designed by STOXX, an index provider owned by Deutsche Börse Group. The index is composed of 50 stocks from 11 countries in the Eurozone. EURO STOXX 50 represents Eurozone blue-chip companies considered as leaders in their respective sectors.

STOXX EUROPE 600: - The STOXX Europe 600, also called STOXX 600, SXXP, is a stock index of European stocks designed by STOXX Ltd.

MSCI EUROPE: - The Morgan Stanley Composite Index Europe captures large and mid-cap representation across Developed Markets (DM) countries in Europe. The index covers approximately 85% of the free float-adjusted market capitalization across the European Developed Markets equity universe.

FTSE 100 Index: - The Financial Times Stock Exchange 100 Index, also called the FTSE 100 Index, FTSE 100, FTSE, or, informally, the "Footsie", is the United Kingdom's best-known stock market index of the 100 most highly capitalised blue chips listed on the London Stock Exchange.

CAC 40 Index: - The CAC 40 is a benchmark French stock market index. The index represents a capitalization-weighted measure of the 40 most significant stocks among the 100 largest market caps on the Euronext Paris. It is a price return index.

DAX Index DAX: - The DAX is a stock market index consisting of the 40 major German blue chip companies trading on the Frankfurt Stock Exchange. It is a total return index. Prices are taken from the Xetra trading venue.

SMI Index: - The Swiss Market Index is Switzerland's blue-chip stock market index, which makes it the most followed in the country. It is made up of 20 of the largest and most liquid Swiss Performance Index stocks. As a price index, the SMI is not adjusted for dividends.

OMX SPI Index: - The OMX Stockholm PI, formerly known as SAX All Share, is a stock market index of all shares that trade on the Stockholm Stock Exchange

AEX Index: - The AEX index, derived from Amsterdam Exchange index, is a stock market index composed of Dutch companies that trade on Euronext Amsterdam, formerly known as the Amsterdam Stock Exchange. Started in 1983, the index is composed of a maximum of 25 of the most frequently traded securities on the exchange.

WIG20 Index: - The WIG20 is a capitalization-weighted stock market index of the twenty largest companies on the Warsaw Stock Exchange. WIG is an acronym for "Warszawski Indeks Giełdowy", which translates to Warsaw Stock Index in Polish. 

FTSE MIB Index: - The FTSE MIB (Milano Indice di Borsa) (the S&P/MIB prior to June 2009) is the benchmark stock market index for the Borsa Italiana, the Italian national stock exchange, which superseded the MIB-30 in September 2004. The index consists of the 40 most-traded stock classes on the exchange. The index was administered by Standard & Poor's from its inception until June 2009, when this responsibility was passed to FTSE Group, which is 100% owned by the Borsa Italiana's parent company London Stock Exchange Group.

IBEX 35 Index: - The IBEX 35 is the benchmark stock market index of the Bolsa de Madrid, Spain's principal stock exchange. Initiated in 1992, the index is administered and calculated by Sociedad de Bolsas, a subsidiary of Bolsas y Mercados Españoles, the company which runs Spain's securities markets.

LONDON AIM: - AIM (formerly the Alternative Investment Market) is a sub-market of the London Stock Exchange that was launched on 19 June 1995 as a replacement to the previous Unlisted Securities Market (USM) that had been in operation since 1980. It allows companies that are smaller, less-developed, or want/need a more flexible approach to governance to float shares with a more flexible regulatory system than is applicable on the main market. At launch, AIM comprised only 10 companies valued collectively at £82.2 million. As at May 2021, 821 companies comprised the sub-market, with an average market cap of £80 million per listing.[2] AIM has also started to become an international exchange, often due to its low regulatory burden, especially in relation to the US Sarbanes–Oxley Act (though only a quarter of AIM-listed companies would qualify to be listed on a US stock exchange even prior to passage of the Sarbanes–Oxley Act).[3] By December 2005, over 270 foreign companies had been admitted to AIM. The FTSE Group maintains three indices for measuring AIM, which are the FTSE AIM UK 50 Index, FTSE AIM 100 Index, and FTSE AIM All-Share Index.